3-(4-甲氧苯基)-3-氧代丙酸乙酯合成路线 （共 58 条）
反应条件
piperidine in ethanol
T=50°C; Knoevenagel condensation; RefluxInert atmosphere;
参考文献
Medda, Federico; Russell, Rupert J. M.; Higgins, Maureen; McCarthy, Anna R.; Campbell, Johanna; Slawin, Alexandra M. Z.; Lane, David P.; Lain, Sonia; Westwood, Nicholas J.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2673 - 2682
反应条件
pyridinium bromide perbromide; triethylamine in ethanol
T=50°C; 2 h;
参考文献
SAREUM LIMITED
Patent: WO2008/139161 A1, 2008 ;
Location in patent: Page/Page column 89-90 ;
WO 2008/139161 A1
反应条件
1: 75 percent / 30percentaq.KOH / 75 h / Ambient temperature
2: 90 percent / methanol; diethyl ether / 0 °C
View Scheme
参考文献
Irvine, Robert W.; Summers, John C.; Taylor, Walter C.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1419 - 1430
反应条件
potassium hydroxide
75 h; Ambient temperature;
参考文献
Irvine, Robert W.; Summers, John C.; Taylor, Walter C.
Australian Journal of Chemistry, 1983 , vol. 36, # 7 p. 1419 - 1430
反应条件
PPA
T=90 - 100°C; 1 h;
参考文献
Nakazumi, Hiroyuki; Kitaguchi, Tooru; Ueyama, Tamio; Kitao, Teijiro
Synthesis, 1984 , # 6 p. 518 - 520
反应条件
PPA
T=90 - 100°C; 1 h;
参考文献
Nakazumi, Hiroyuki; Kitaguchi, Tooru; Ueyama, Tamio; Kitao, Teijiro
Synthesis, 1984 , # 6 p. 518 - 520
反应条件
piperidine in ethanol
8 h; Reflux;
参考文献
PIERRE FABRE MEDICAMENT; Rabot, Rémi; Bedjeguelal, Karim; Kaloun, El Bachir; Schmitt, Philippe; Rahier, Nicolas; Mayer, Patrice; Fournier, Emmanuel
Patent: US2014/31362 A1, 2014 ;
Location in patent: Paragraph 0302; 0303; 0304; 0305 ;
反应条件
1-propanephosphonic acid cyclic anhydride in ethyl acetate
T=100°C; 0.0833333 h; Microwave irradiationSealed tube;
参考文献
Desroses, Matthieu; Jacques-Cordonnier, Marie-Caroline; Llona-Minguez, Sabin; Jacques, Sylvain; Koolmeister, Tobias; Helleday, Thomas; Scobie, Martin
European Journal of Organic Chemistry, 2013 , # 26 p. 5879 - 5885
