1-Boc-4-(Cbz-氨基)哌啶-4-甲酸合成路线 （共 12 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=0 - 20°C; 24 h; 2: With hydrogenchloride; water pH=2.5;
参考文献
ILDONG PHARMACEUTICAL CO., LTD.
Patent: US2010/168421 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With water; sodium carbonate in 1,4-dioxane T=20°C; 6 h; 2: With hydrogenchloride in water
参考文献
LG LIFE SCIENCES LTD.; YAMANOUCHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/47253 A1, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/047253 A1
反应条件
aq. sodium hydroxide in ethylene glycol dimethyl ether; aqueous sodium hydroxide
参考文献
Davies, David Thomas; Markwell, Roger Edward; Pearson, Neil David
Patent: US2004/53928 A1, 2004 ;
反应条件
potassium carbonate in 1,4-dioxane; water T=20°C;
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 2: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C 3: 78 percent / K2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: 75 percent / methanol; H2O / 72 h / 20 °C 2: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 3: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C 4: 78 percent / K2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 2: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C 3: 78 percent / K2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C 2: 78 percent / K2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether T=-15°C; 2: With ammonia in ethylene glycol dimethyl ether T=20°C;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2009/253725 A1, 2009 ;
Location in patent: Page/Page column 51 ;
反应条件
1: NMM / 1,2-dimethoxy-ethane / 0.08 h / -15 °C 2: aq. NH3 / 1,2-dimethoxy-ethane / 1 h / 20 °C 3: 100 percent / aq. HCl / 10percent Pd/C / ethanol / 20 °C View Scheme
参考文献
Bedos, Philippe; Amblard, Muriel; Subra, Gilles; Dodey, Pierre; Luccarini, Jean-Michel; Paquet, Jean-Luc; Pruneau, Didier; Aumelas, Andre; Martinez, Jean
Journal of Medicinal Chemistry, 2000 , vol. 43, # 12 p. 2387 - 2394
