1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether T=-15°C; 2: With ammonia in ethylene glycol dimethyl ether T=20°C;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2009/253725 A1, 2009 ;
Location in patent: Page/Page column 51 ;