Z-L-丙氨酸甲酯合成路线

参考文献

GLAXO GROUP LIMITED
Patent: WO2009/74590 A1, 2009 ;
Location in patent: Page/Page column 64 ;
WO 2009/074590 A1

参考文献

Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1893 - 1901

67-56-1甲醇+

1142-20-7N-苄氧羰基-L-丙氨酸

28819-05-8Z-L-丙氨酸甲酯

参考文献

Nuijens, Timo; Cusan, Claudia; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5145 - 5150

21149-17-7苄基-脱氢-丙氨酸甲酯

28819-05-8Z-L-丙氨酸甲酯

参考文献

Cristobal-Lecina, Edgar; Etayo, Pablo; Doran, Sean; Reves, Marc; Martin-Gago, Pablo; Grabulosa, Arnald; Costantino, Andrea R.; Vidal-Ferran, Anton; Riera, Antoni; Verdaguer, Xavier
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 795 - 804

1142-20-7N-苄氧羰基-L-丙氨酸+

74-88-4甲基碘

28819-05-8Z-L-丙氨酸甲酯

参考文献

Bayer, Annette; Endeshaw, Molla Mellese; Gautun, Odd R.
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21149-17-7苄基-脱氢-丙氨酸甲酯

28819-05-8Z-L-丙氨酸甲酯

参考文献

Pye; Rossen; Reamer; Tsou; Volante; Reider
Journal of the American Chemical Society, 1997 , vol. 119, # 26 p. 6207 - 6208

1142-20-7N-苄氧羰基-L-丙氨酸+

77-78-1硫酸二甲酯

28819-05-8Z-L-丙氨酸甲酯

参考文献

Wyslouch, Aleksandra; Lisowski, Marek; Pedyczak, Artur; Siemion, Ignacy Z.
Tetrahedron: Asymmetry, 1992 , vol. 3, # 11 p. 1401 - 1410

105417-41-2+

20194-18-7苯甲醇钠

28819-05-8Z-L-丙氨酸甲酯

参考文献

Anbazhagan, Mariappan; Reddy, T. Indrasena; Rajappa, Srinivasachari
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 11 p. 1623 - 1627

67-56-1甲醇+

4132-86-9N-Cbz-DL-丙氨酸

26607-51-2N-苄氧羰基-D-丙氨酸+

28819-05-8Z-L-丙氨酸甲酯

参考文献

Moriniere, J. L.; Danree, B.; Lemoine, J.; Guy, A.
Synthetic Communications, 1988 , vol. 18, # 4 p. 441 - 444

1142-20-7N-苄氧羰基-L-丙氨酸+

159390-21-3

28819-05-8Z-L-丙氨酸甲酯

参考文献

Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507