(3S,4s)-3,4-二叠氮基-1-(苯基甲基)吡咯烷合成路线 (共 7 条)
反应条件
hydrogen; MCM-silylamine Pd(II) in methanol T=20°C; Reduction; 2 h;
参考文献
Kantam, M. Lakshmi; Chowdari, N. Srcenivasa; Rahman, Ateeq; Choudary
Synlett, 1999 , # 9 p. 1413 - 1414
反应条件
1: LiAlH4 / tetrahydrofuran / 0.5 h / Heating 2: 1.5 g / NaOH / H2O; dioxane / 2 h / 20 °C View Scheme
参考文献
Brouwer, Arwin J.; van Der Linden, Heiko J.; Liskamp, Rob M. J.
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1750 - 1757
反应条件
tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate
Substitution;
参考文献
Brouwer, Arwin J.; van Der Linden, Heiko J.; Liskamp, Rob M. J.
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1750 - 1757
反应条件
1: 67 percent / NaBH4; BF3*Et2O
2: 95 percent / HN3; DEAD; PPh3
View Scheme
参考文献
Brouwer, Arwin J.; van Der Linden, Heiko J.; Liskamp, Rob M. J.
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1750 - 1757
反应条件
1: 67 percent / xylene / Heating
2: 67 percent / NaBH4, I2 / tetrahydrofuran / 6 h / Heating
3: 72 percent / triphenylphosphine, diethyl azodicarboxylate, azidoic acid / benzene / 3 h / Ambient temperature
View Scheme
参考文献
Skarzewski, Jacek; Gupta, Anil
Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1861 - 1867
反应条件
1: triethylamine / dichloromethane
2: sodium azide / N,N-dimethyl-formamide / 100 °C
View Scheme
参考文献
Andrews, Kim M.; Beebe, David A.; Benbow, John W.; Boyer, David A.; Doran, Shawn D.; Hui, Yu; Liu, Shenping; McPherson, R. Kirk; Neagu, Constantin; Parker, Janice C.; Piotrowski, David W.; Schneider, Steven R.; Treadway, Judith L.; Vanvolkenberg, Maria A.; Zembrowski, William J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1810 - 1814
反应条件
1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 0 °C
2: triethylamine / dichloromethane
3: sodium azide / N,N-dimethyl-formamide / 100 °C
View Scheme
参考文献
Andrews, Kim M.; Beebe, David A.; Benbow, John W.; Boyer, David A.; Doran, Shawn D.; Hui, Yu; Liu, Shenping; McPherson, R. Kirk; Neagu, Constantin; Parker, Janice C.; Piotrowski, David W.; Schneider, Steven R.; Treadway, Judith L.; Vanvolkenberg, Maria A.; Zembrowski, William J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1810 - 1814