3,3-二氟三甲叉亚胺盐酸盐合成路线 （共 5 条）
反应条件
sodium tris(acetoxy)borohydride T=20°C; 17 h;
参考文献
WO2008/152394 A1, ;
Page/Page column 45 ;
WO 2008/152394 A1
反应条件
triethylamine in dichloromethane T=20°C; 0.25 h;
参考文献
WO2007/40440 A1, ;
Page/Page column 115-116 ;
WO 2007/040440 A1
反应条件
1: 9-methoxy-2,3-dimethyl-9-(2-methylphenyl)-7H-8,9-dihydro-pyrano[2,3-c]-imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=50°C; 2 h; 2: 3,3-difluoroazetidine hydrogen chloride salt in N,N-dimethyl-formamide T=50°C; 4 h;
参考文献
WO2007/141253 A1, ;
Page/Page column 67 ;
反应条件
1: 9-methoxy-2,3-dimethyl-9-(2-methylphenyl)-7H-8,9-dihydro-pyrano[2,3-c]-imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=50°C; 2 h; 2: 3,3-difluoroazetidine hydrogen chloride salt in N,N-dimethyl-formamide T=50°C; 4 h;
参考文献
NYCOMED GMBH
Patent: WO2007/141253 A1, 2007 ;
Location in patent: Page/Page column 67 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=55°C; 5 h;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2007/4049 A1, 2007 ;
Location in patent: Page/Page column 23 ;
