7-氯-5-(2-氟苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮合成路线 （共 22 条）
反应条件
1: 1. potassium t-butoxide, diethyl chlorophosphate; 2. potassium t-butoxide / 1. THF, 10min.; 2. DMF, 1h 2: 98 percent / trifluoroacetic acid / 2 h / Ambient temperature 3: 82 percent / xylene / 0.5 h / Heating 4: 78 percent / conc. H2SO4 / Ambient temperature; overnight View Scheme
参考文献
Walser; Flynn
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 3 p. 683 - 688
反应条件
sodium methylate in N-methyl-acetamide; methanol; ice-water; water; ethyl acetate
参考文献
Hoffmann-La Roche Inc.
Patent: US3963777 A1, 1976 ;
