7-苄基-1,3,7-三氮杂螺[4.4]-2,4-壬二酮合成路线 （共 5 条）
反应条件
1: 73 percent / conc. aq. HCl; AcOH; HBr / 96 h / Heating 2: 93 percent / HCl / 2 h / Heating 3: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 3 h / Heating 4: 82 percent / CH2Cl2 / 2 h / 0 °C View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
1: 73 percent / conc. aq. HCl; AcOH; HBr / 96 h / Heating 2: 93 percent / HCl / 2 h / Heating 3: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 3 h / Heating View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
1: 73 percent / conc. aq. HCl; AcOH; HBr / 96 h / Heating 2: 93 percent / HCl / 2 h / Heating 3: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 3 h / Heating 4: 82 percent / CH2Cl2 / 2 h / 0 °C 5: H2 / 5percent Pd/C / ethanol / 3.5 h / 50 °C View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
1: 73 percent / conc. aq. HCl; AcOH; HBr / 96 h / Heating 2: 93 percent / HCl / 2 h / Heating View Scheme
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
反应条件
hydrogenchloride; hydrogen bromide; acetic acid 96 h; Heating;
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575
