3',5'-二溴-4'-羟基苯乙酮合成路线 (共 9 条)
反应条件
bromine; sodium acetate in acetic acid 1 h;
参考文献
Marshall, Laura J.; Cable, Karl M.; Botting, Nigel P.
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 5-6 p. 315 - 318
反应条件
1: pyridine 2: AlCl3 / 120 °C View Scheme
参考文献
Nitto Boseki Co., Ltd.
Patent: US5081274 A1, 1992 ;
反应条件
N-bromosuccinmide; lithium perchlorate; silica gel in dichloromethane T=20°C; 0.0833333 h;
参考文献
Heravi, Majid M.; Abdolhosseini, Nafiseh; Oskooie, Hossein A.
Tetrahedron Letters, 2005 , vol. 46, # 51 p. 8959 - 8963
反应条件
copper diacetate; ethylene glycol T=100°C; 12 h; Green chemistry; chemoselective reaction;
参考文献
Jiang, Jian-An; Chen, Cheng; Huang, Jian-Gang; Liu, Hong-Wei; Cao, Song; Ji, Ya-Fei
Green Chemistry, 2014 , vol. 16, # 3 p. 1248 - 1254
反应条件
aluminium trichloride T=120°C;
参考文献
Joshi; Shah
Journal of the Indian Chemical Society, 1954 , vol. 31, p. 223,229
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 1 h 1.2: 14 h 2.1: bromine; acetic acid / water / 3 h View Scheme
参考文献
Olusanjo, Moniola S.; Mashru, Shreena N.; Cartledge, Timothy; Ahmed, Sabbir
Letters in Drug Design and Discovery, 2012 , vol. 9, # 6 p. 604 - 610
反应条件
CuSO4‵5H2O; sodium hydroxide in water 18 h; Reflux;
参考文献
Marshall, Laura J.; Cable, Karl M.; Botting, Nigel P.
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 5-6 p. 315 - 318
反应条件
potassium carbonate in acetone
2 h; Inert atmosphereReflux;
参考文献
Jin, Huijuan; Zhang, Puyong; Bijian, Krikor; Ren, Sumei; Wan, Shengbiao; Alaoui-Jamali, Moulay A.; Jiang, Tao
Marine Drugs, 2013 , vol. 11, # 5 p. 1427 - 1439
反应条件
1: CuSO4‵5H2O; sodium hydroxide / water / 18 h / Reflux
2: 18-crown-6 ether; potassium carbonate / acetone / 6 h / Reflux
View Scheme
参考文献
Marshall, Laura J.; Cable, Karl M.; Botting, Nigel P.
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 5-6 p. 315 - 318