Boc-L-丙氨酸甲基酯合成路线 （共 43 条）
反应条件
1: N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-L-alanine methyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc in tetrahydrofuran T=45°C; 1.45 h; 2: thioacetic acid S-ethyl ester With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=45°C; 4.5 h;
参考文献
Estiarte, M.Angels; Diez, Anna; Rubiralta, Mario; Jackson, Richard F.W
Tetrahedron, 2001 , vol. 57, # 1 p. 157 - 161
反应条件
in dichloromethane T=20°C; 3 h;
参考文献
Erb, Bernhard; Kucma, Jean-Philippe; Mourey, Sandrine; Struber, Fritz
Chemistry - A European Journal, 2003 , vol. 9, # 11 p. 2582 - 2588
反应条件
copper(II) bis(trifluoromethanesulfonate) T=20°C; 12 h; solid phase reaction;
参考文献
Nyasse, Barthelemy; Grehn, Leif; Ragnarsson, Ulf
Chemical Communications, 1997 , # 11 p. 1017 - 1018
反应条件
1: With bis (triortho-tolylphosphine)palladium(II) chloride; zinc in tetrahydrofuran; N,N-dimethyl acetamide T=60°C; Condensation; 3 h; 2: With hydrogen; palladium on activated charcoal in tetrahydrofuran T=20°C; Hydrogenolysis; 21 h;
参考文献
Kendall, John T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 505 - 514
反应条件
in acetonitrile T=20°C;
参考文献
Sameiro, M; Goncalves, T; Maia, Hernani L.S
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7775 - 7777
Title/Abstract Full Text View citing articles Show Details
Sameiro; Goncalves; Maia, Hernani L.S.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 9 p. 1480 - 1485
反应条件
1: methanol; [3H]-L-Alanine With thionyl chloride Heating; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; Further stages.;
参考文献
Zhang, Zuhui; Zhang, Jintang; Tan, Jiajing; Wang, Zhiyong
Journal of Organic Chemistry, 2008 , vol. 73, # 13 p. 5180 - 5182
反应条件
copper(II) bis(trifluoromethanesulfonate) T=20°C; 16 h;
参考文献
Broehmer, Manuel C.; Mundinger, Stephan; Braese, Stefan; Bannwarth, Willi
Angewandte Chemie - International Edition, 2011 , vol. 50, # 27 p. 6175 - 6177
反应条件
1-amino-2-diethylamino-ethane 48 h;
参考文献
Fraga, Susana M. B.; Goncalves, Maria S. T.; Moura, Joao C. V. P.; Rani, Kavitha
European Journal of Organic Chemistry, 2004 , # 8 p. 1750 - 1760
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; zinc in tetrahydrofuran; N,N-dimethyl acetamide T=60°C; Condensation; reduction; 3 h; Title compound not separated from byproducts;
参考文献
Kendall, John T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 505 - 514
反应条件
1: 86 percent / NaH / tetrahydrofuran 2: 1.) n-BuLi, (-)-sparteine / 1.) toluene, -78 deg C, 4 h, 2.) toluene, -78 deg C -> room temperature 3: ammonium cerium(IV) nitrate / acetonitrile; H2O / 0.5 h / 0 °C 4: NaIO4, RuCl3*H2O / CCl4; acetonitrile; H2O / 48 h / Ambient temperature 5: 1.) thionyl chloride, 2.) di-tert-butyl dicarbonate / 1.) 2 h, 2.) CH2Cl2 View Scheme
参考文献
Kim, Bong Jin; Park, Yong Sun; Beak, Peter
Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1705 - 1708
