Boc-L-丙氨酸甲基酯合成路线 （共 43 条）
反应条件
1: NaIO4, RuCl3*H2O / CCl4; acetonitrile; H2O / 48 h / Ambient temperature 2: 1.) thionyl chloride, 2.) di-tert-butyl dicarbonate / 1.) 2 h, 2.) CH2Cl2 View Scheme
参考文献
Kim, Bong Jin; Park, Yong Sun; Beak, Peter
Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1705 - 1708
反应条件
1: 1.) n-BuLi, (-)-sparteine / 1.) toluene, -78 deg C, 4 h, 2.) toluene, -78 deg C -> room temperature 2: ammonium cerium(IV) nitrate / acetonitrile; H2O / 0.5 h / 0 °C 3: NaIO4, RuCl3*H2O / CCl4; acetonitrile; H2O / 48 h / Ambient temperature 4: 1.) thionyl chloride, 2.) di-tert-butyl dicarbonate / 1.) 2 h, 2.) CH2Cl2 View Scheme
参考文献
Kim, Bong Jin; Park, Yong Sun; Beak, Peter
Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1705 - 1708
反应条件
1: ammonium cerium(IV) nitrate / acetonitrile; H2O / 0.5 h / 0 °C 2: NaIO4, RuCl3*H2O / CCl4; acetonitrile; H2O / 48 h / Ambient temperature 3: 1.) thionyl chloride, 2.) di-tert-butyl dicarbonate / 1.) 2 h, 2.) CH2Cl2 View Scheme
参考文献
Kim, Bong Jin; Park, Yong Sun; Beak, Peter
Journal of Organic Chemistry, 1999 , vol. 64, # 5 p. 1705 - 1708
反应条件
triethylamine in dichloromethane 12 h; Ambient temperature; Yield given;
参考文献
Jares-Erijman, Elizabeth A.; Bapat, Chintamani P.; Lithgow-Bertelloni, Anna; Rinehart, Kenneth L.; Sakai, Ryuichi
Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5732 - 5737
参考文献
Mori, Kenji; Matsuda, Hiroyuki
Liebigs Annalen der Chemie, 1992 , # 2 p. 131 - 138
反应条件
N,N,N',N'-tetramethylguanidine in N,N-dimethyl-formamide
参考文献
Ali,A. et al.
Angewandte Chemie, 1972 , vol. 84, p. 259
参考文献
Keglevic,D. et al.
Carbohydrate Research, 1972 , vol. 22, p. 245 - 256
反应条件
1.1: DIBAL-H / toluene; methanol / 0.5 h / -78 °C 1.2: 72 percent / toluene / 12 h / -78 °C 2.1: 61 percent / 10 percent aq. NaOH / methanol / 18 h / 20 °C View Scheme
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
参考文献
Wang, Jia; Liang, Yan-Liang; Qu, Jin
Chemical Communications, 2009 , # 34 p. 5144 - 5146
反应条件
diisobutylaluminium hydride in toluene T=-78°C;
参考文献
Jones, Raymond C. F.; Seager, Laura E.; Elsegood, Mark R. J.
Synlett, 2011 , # 2 art. no. G25510ST, p. 211 - 214
