Boc-L-丙氨酸甲基酯合成路线 （共 43 条）
反应条件
hydrogenchloride in toluene
参考文献
Merrell Pharmaceuticals Inc.
Patent: US5496927 A1, 1996 ;
反应条件
ammonium hydroxide in methanol; water
参考文献
Singh, Erinprit K.; Ramsey, Deborah M.; McAlpine, Shelli R.
Organic Letters, 2012 , vol. 14, # 5 p. 1198 - 1201
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
Rengasamy, Rajesh; Curtis-Long, Marcus J.; Woo, Duck Seo; Seong, Hun Jeong; Jeong, Ill-Yun; Ki, Hun Park
Journal of Organic Chemistry, 2008 , vol. 73, # 7 p. 2898 - 2901
反应条件
ammonium hydroxide in methanol; water
参考文献
Singh, Erinprit K.; Ramsey, Deborah M.; McAlpine, Shelli R.
Organic Letters, 2012 , vol. 14, # 5 p. 1198 - 1201
反应条件
1.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C / Inert atmosphere 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 2 h / 0 °C / Inert atmosphere 3.1: mercury(II) diacetate; water / tetrahydrofuran / 23 h / 0 - 20 °C / Inert atmosphere 4.1: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / water; acetonitrile / 1 h / 0 °C / Inert atmosphere View Scheme
参考文献
Sugimoto, Kenji; Kobayashi, Yuta; Hori, Ayana; Kondo, Takashi; Toyooka, Naoki; Nemoto, Hideo; Matsuya, Yuji
Tetrahedron, 2011 , vol. 67, # 40 p. 7681 - 7685
反应条件
4-methyl-morpholine in water; acetonitrile T=30°C; P=7500600 Torr; 96 h;
参考文献
Yamamoto, Yoshinori; Furuta, Toshiaki; Matsuo, Jiro; Kurata, Tetsuro
Journal of Organic Chemistry, 1991 , vol. 56, # 20 p. 5737 - 5738
反应条件
hydrogenchloride in ethyl acetate T=0°C; 2 h;
参考文献
Tamiaki; Kiyomori; Maruyama
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 9 p. 2478 - 2486
参考文献
Sharma, Gangavaram V. M.; Babu, Bommagani Shoban; Ramakrishna, Kallaganti V. S.; Nagendar, Pendem; Kunwar, Ajit C.; Schramm, Peter; Baldauf, Carsten; Hofmann, Hans-Joerg
Chemistry - A European Journal, 2009 , vol. 15, # 22 p. 5552 - 5566
反应条件
hydrogen; sodium methylate; trans-RuCl2(Ph2P(CH2)3NH2)2 in tetrahydrofuran
T=80°C; P=37503.8 Torr; 18 h; Product distribution / selectivity;
参考文献
TAKASAGO INTERNATIONAL CORPORATION
Patent: US2010/63294 A1, 2010 ;
Location in patent: Page/Page column 18 ;
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C;
参考文献
Gissot, Arnaud; Volonterio, Alessandro; Zanda, Matteo
Journal of Organic Chemistry, 2005 , vol. 70, # 17 p. 6925 - 6928
