2-溴-6-碘-4-甲基苯胺合成路线 （共 3 条）
反应条件
N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate in methanol; dichloromethane T=20°C; 21 h; Inert atmosphere;
参考文献
Guthrie, David B.; Curran, Dennis P.
Organic Letters, 2009 , vol. 11, # 1 p. 249 - 251
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78°C;
参考文献
Petit, Marc; Geib, Steven J.; Curran, Dennis P.
Tetrahedron, 2004 , vol. 60, # 35 p. 7543 - 7552
反应条件
1: LDA / tetrahydrofuran / -78 °C
2: 85 percent / s-BuLi / tetrahydrofuran / -78 °C
3: CH2Cl2
4: NaOH / ethanol
5: Et3N / tetrahydrofuran / 0 °C
6: tetrahydrofuran
7: aq. H2O2 / tetrahydrofuran
8: Bu3SnH; Et3B / benzene / 25 °C
9: 76 percent / TBAF / tetrahydrofuran / 0 °C
View Scheme
参考文献
Petit, Marc; Geib, Steven J.; Curran, Dennis P.
Tetrahedron, 2004 , vol. 60, # 35 p. 7543 - 7552
