4-(4-氟苯基)-6-异丙基-2-[(N-甲基-N-甲磺酰)氨基]嘧啶-5-羧酸甲酯合成路线 （共 15 条）
反应条件
in N,N-dimethyl-formamide T=30°C; 1 h;
参考文献
WO2007/74391 A2, ;
Page/Page column 16 ;
反应条件
sodium t-butanolate in methanol; water; tert-butyl alcohol
反应条件
1: 6-(4'-fluorophenyl)-4-isopropyl-5-methoxycarbonyl-2-(methylamino)pyrimidine With sodium tert-pentoxide in ethylene glycol dimethyl ether T=20°C; 0.5 h; 2: methanesulfonyl chloride in ethylene glycol dimethyl ether T=-10°C; 0.5 h;
参考文献
WO2004/103977 A2, ;
Page 22-23 ;
反应条件
potassium carbonate in acetonitrile T=25 - 85°C; 2.5 - 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2008/59519 A2, ;
Page/Page column 8; 16; 20-21 ;
反应条件
sodium t-butanolate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; tert-butyl alcohol
反应条件
1: methyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-pyrimidine-5-carboxylate With sodium tert-pentoxide in ethylene glycol dimethyl ether T=25°C; 0.5 h; 2: methanesulfonyl chloride in ethylene glycol dimethyl ether T=-10 - -5°C; 0.333333 h; 3: With sodium tert-pentoxide; dimethyl sulfate more than 3 stages;
参考文献
US2004/49036 A1, ;
Page 3 ;
反应条件
in N,N-dimethyl acetamide; water
反应条件
sodium t-butanolate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; tert-butyl alcohol
反应条件
sodium chloride; dimethyl sulfate in ethylene glycol dimethyl ether; water
