4-(4-氟苯基)-6-异丙基-2-[(N-甲基-N-甲磺酰)氨基]嘧啶-5-羧酸甲酯合成路线 （共 15 条）
反应条件
potassium carbonate in acetic acid n-butyl ester T=90°C; Product distribution / selectivity;
参考文献
EP1849765 A1, ;
Page/Page column 15-16 ;
反应条件
in N,N-dimethyl acetamide; isobutyramide; water
反应条件
1: methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate With diisobutylaluminium hydride in toluene T=-10 - 0°C; 2.5 h; 2: With hydrogenchloride in methanol; water; acetonitrile T=0 - 40°C; 2.83333 h; 3: ethoxydiphenylphosphane With phosphorus tribromide more than 3 stages;
参考文献
US2004/49036 A1, ;
Page 2; 3 ;
反应条件
1: With diisobutylaluminium hydride in hexane; toluene T=-10°C; 1 h; 2: With hydrogenchloride in methanol; hexane; water; toluene T=-10 - 40°C; 0.333333 h;
参考文献
CIBA SPECIALTY CHEMICALS HOLDING INC.
Patent: WO2004/103977 A2, 2004 ;
Location in patent: Page 23 ;
