2-甲基-3-呋喃羧酸乙酯合成路线 （共 24 条）
反应条件
sodium hydride 1.) THF, 2.) 50 deg C, 5 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Cambie, R.C.; Moratti, S.C.; Rutledge, P.S.; Woodgate, P.D.
Synthetic Communications, 1990 , vol. 20, # 13 p. 1923 - 1929
反应条件
in benzene T=80°C; 4 h; Yield given. Title compound not separated from byproducts;
参考文献
Pevzner, L. M.; Ignat'ev, V. M.; Ionin, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1992 , vol. 62, # 4.1 p. 797 - 803,658 - 662
反应条件
1: 95 percent / 20percent aq. NaOH / 2 h / Heating 2: 87.3 percent / SOCl2 / 24 h / 40 °C View Scheme
参考文献
Trahanovsky, Walter S.; Huang, Yih-chuan Jason; Leung, Man-kit
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2594 - 2598
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 0°C; 5 h;
参考文献
WO2005/105802 A1, ;
Page/Page column 110 ;
WO 2005/105802 A1
反应条件
1: 87 percent / LiAlH4 / diethyl ether / 2 h / Heating 2: SOCl2; pyridine; Na2CO3 / petroleum ether; diethyl ether / 1.25 h / 0 - 20 °C View Scheme
参考文献
Espaze, Florence; Hamon, Jacques; Hirbec, Helene; Vignon, Jacques; Kamenka, Jean-Marc
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 3 p. 323 - 331
反应条件
1: aluminium chloride; carbon disulfide 2: aqueous KOH-solution View Scheme
参考文献
Messina; Brown
Journal of the American Chemical Society, 1952 , vol. 74, p. 1087
反应条件
trichlorophosphate T=0 - 20°C; Inert atmosphere of N2;
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 126-127 ;
WO 2010/020556 A1
参考文献
Pitucha, Monika; Karczmarzyk, Zbigniew; Kosikowska, Urszula; Malm, Anna
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2011 , vol. 66, # 5 p. 505 - 511
反应条件
sodium hydroxide 2 h; Heating;
参考文献
Trahanovsky, Walter S.; Huang, Yih-chuan Jason; Leung, Man-kit
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2594 - 2598
反应条件
1: 87 percent / LiAlH4 / diethyl ether / 2 h / Heating 2: SOCl2; pyridine; Na2CO3 / petroleum ether; diethyl ether / 1.25 h / 0 - 20 °C 3: 8.2 g / LiAlH4 / bis-(2-methoxy-ethyl) ether / 16 h / 20 °C View Scheme
参考文献
Espaze, Florence; Hamon, Jacques; Hirbec, Helene; Vignon, Jacques; Kamenka, Jean-Marc
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 3 p. 323 - 331
