4-苄氧基-2,6-二甲基苯甲醛合成路线 （共 7 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 1 h;
参考文献
Aicher, Thomas Daniel; Anzeveno, Peter Biagio; Li, Renhua; Krasutsky, Alexei Pavlovych; Mabry, Thomas Edward; Saeed, Ashraf; Snyder, Nancy June; Stephenson, Gregory Alan; Tian, Hongqi; Wallace, Owen Brendan; Winneroski, JR., Leonard Larry; Xu, Yanping
Patent: US2009/111800 A1, 2009 ;
Location in patent: Page/Page column 39 ;
US 20090111800 A1
反应条件
1: 1-((4-bromo-3,5-dimethylphenoxy)methyl)benzene With iodine; magnesium in tetrahydrofuran Grignard reaction; 1 h; Heating; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0 - 20°C; Formylation;
参考文献
Tang, Xuejun; Soloshonok, Vadim A.; Hruby, Victor J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2917 - 2925
反应条件
1.1: 78 percent / K2CO3 / dimethylformamide / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C 2.2: 80 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C View Scheme
参考文献
Tang, Xuejun; Soloshonok, Vadim A.; Hruby, Victor J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2917 - 2925
反应条件
potassium carbonate in N,N-dimethyl-formamide T=140°C;
参考文献
Ogiso,A. et al.
Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, # 6 p. 1283 - 1286
反应条件
1.1: 78 percent / K2CO3 / dimethylformamide / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C 2.2: 80 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C View Scheme
参考文献
Yoshihara, Hikari A. I.; Apriletti, James W.; Baxter, John D.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 3152 - 3161
反应条件
1.1: NaOH / methanol / 2 h / 0 °C 1.2: 97 percent / 1,2-dimethoxy-ethane / 24 h / 35 °C 2.1: I2; Mg / tetrahydrofuran / 1 h / Heating 2.2: 90 percent / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Tang, Xuejun; Soloshonok, Vadim A.; Hruby, Victor J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2917 - 2925
反应条件
1: 92 percent / LiALH4 / tetrahydrofuran / 4 h / Heating 2: 83 percent / PBr3; pyridine / diethyl ether / -78 - 20 °C View Scheme
参考文献
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563,5
Title/Abstract Full Text Show Details
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563
