3-甲基-3-苯基-2-环氧乙烷甲腈合成路线 （共 5 条）
反应条件
1: 69 percent / pyridine / 120 h / Ambient temperature 2: 83 percent / KOH / 2 h / Ambient temperature View Scheme
参考文献
Althoff, Wolfgang; Tinapp, Peter
Archiv der Pharmazie (Weinheim, Germany), 1982 , vol. 315, # 4 p. 289 - 294
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide
1.) THF, -78 deg C, 15 min; 2.) THF, -35 deg C, 1 h; 3.) methanol, H2O; Multistep reaction;
参考文献
Makosza, M.; Pankowski, J.
Bulletin des Societes Chimiques Belges, 1985 , vol. 94, # 3 p. 235 - 236
反应条件
pyridine
120 h; Ambient temperature;
参考文献
Althoff, Wolfgang; Tinapp, Peter
Archiv der Pharmazie (Weinheim, Germany), 1982 , vol. 315, # 4 p. 289 - 294
反应条件
1: 68 percent / acid / 24 h / Heating
2: 55 percent / pyridine / 1.5 h / Heating
View Scheme
参考文献
Althoff, Wolfgang; Tinapp, Peter
Archiv der Pharmazie (Weinheim, Germany), 1982 , vol. 315, # 4 p. 289 - 294
反应条件
Multi-step reaction with 2 steps 1: 52 percent / InBr / tetrahydrofuran / 10 h / -5 °C2: 100 percent Spectr. / NEt3 / methanol / 3 h / 5 °C
参考文献
Nobrega; Goncalves, Simone M. C.; Peppe Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5779 - 5782
