2-甲基-4,5-二溴-2H-1,2,3-三唑合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran 1.) room temp., 10 min, 2.) reflux, 16 h;
参考文献
SYNGENTA LIMITED
Patent: WO2007/71900 A1, 2007 ;
Location in patent: Page/Page column 112 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=-10 - 20°C;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe
Patent: WO2012/151512 A2, 2012 ;
Location in patent: Page/Page column 151 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide regioselective reaction;
参考文献
Wang, Xiao-Jun; Zhang, Li; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.; Wipf, Peter
Organic Letters, 2010 , vol. 12, # 20 p. 4632 - 4635
反应条件
tetrachloromethane; bromine; iron
参考文献
Huettel, Rudolf; Schaefer, Otto; Jochum, Peter
Justus Liebigs Annalen der Chemie, 1955 , vol. 593, p. 200 - 207
反应条件
1: 4,5-dibromo-2-methyl-1,2,3-triazole; 1-methyl-4,5-dibromo-1H-1,2,3-triazole With n-butyllithium in tetrahydrofuran T=-80°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran T=-80°C; 2 h;
参考文献
SYNGENTA LIMITED
Patent: WO2007/96576 A1, 2007 ;
Location in patent: Example I22 ;
反应条件
1: 4,5-dibromo-2-methyl-1,2,3-triazole; 1-methyl-4,5-dibromo-1H-1,2,3-triazole With n-butyllithium in tetrahydrofuran T=-80°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran T=-80°C; 2 h;
参考文献
SYNGENTA LIMITED
Patent: WO2007/96576 A1, 2007 ;
Location in patent: Example I22 ;
反应条件
n-butyllithium in tetrahydrofuran T=-78°C;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe
Patent: WO2012/151512 A2, 2012 ;
Location in patent: Page/Page column 151 ;
