2-氨基-4'-氯二苯甲酮合成路线 （共 30 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-100°C; 0.333333 h;
参考文献
Frye, Stephen V.; Johnson, Marty C.; Valvano, Nicole L.
Journal of Organic Chemistry, 1991 , vol. 56, # 11 p. 3750 - 3752
反应条件
gallium(III) chloride; boron trichloride in chlorobenzene T=100°C; 20 h;
参考文献
Houpis, Ioannis N.; Molina, Audrey; Douglas, Alan W.; Xavier, Lyndon; Lynch, Joseph; et al.
Tetrahedron Letters, 1994 , vol. 35, # 37 p. 6811 - 6814
反应条件
1: With zinc(II) chloride T=220 - 230°C; 3 h; 2: With sulfuric acid; acetic acid in water Heating;
参考文献
Rizzetto, Elisa; Castellano; Florio; Vadori; Stefancich
Pharmazie, 2006 , vol. 61, # 6 p. 505 - 510
反应条件
hydrogenchloride in water T=125°C; 3 h;
参考文献
Szabo, Fruzsina; Simko, Daniel; Novak, Zoltan
RSC Advances, 2014 , vol. 4, # 8 p. 3883 - 3886
反应条件
1: 75 percent / triethylamine / aq. ethanol / 1.5 h / Heating 2: 55 percent / n-BuLi / tetrahydrofuran; hexane / 0.33 h / -100 °C View Scheme
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
反应条件
aluminium trichloride; phosphorus pentachloride; chlorobenzene weiteres Reagens: H2SO4;
参考文献
Hu, Wenhui; Guo, Zongru; Chu, Fengming; Bai, Aiping; Yi, Xiang; Cheng, Guifang; Li, Jing
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1153 - 1160
反应条件
aluminium trichloride T=18 - 20°C; 0.75 h;
参考文献
Misra, B. K.; Rao, Y. R.; Mahapatra, S. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 11 p. 1132 - 1138
反应条件
1: 68.7 percent / Na2CO3 / H2O / 60 - 85 °C 2: PCl5 / benzene / 0.5 h / 50 °C 3: AlCl3 / 4 h / 80 - 90 °C 4: conc. H2SO4 / 0.25 h / 120 °C View Scheme
参考文献
Hu, Wenhui; Guo, Zongru; Chu, Fengming; Bai, Aiping; Yi, Xiang; Cheng, Guifang; Li, Jing
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1153 - 1160
反应条件
potassium carbonate T=80°C; Suzuki Coupling; P=760.051 Torr; 12 h; Green chemistry;
参考文献
Niu, Jian-Rui; Huo, Xing; Zhang, Feng-Wei; Wang, Hai-Bo; Zhao, Ping; Hu, Wu-Quan; Ma, Jiantai; Li, Rong
ChemCatChem, 2013 , vol. 5, # 1 p. 349 - 354
反应条件
1: palladium diacetate; trifluoroacetic acid; tert.-butylhydroperoxide / water / 24 h / 20 °C 2: hydrogenchloride / water / 3 h / 125 °C View Scheme
参考文献
Szabo, Fruzsina; Simko, Daniel; Novak, Zoltan
RSC Advances, 2014 , vol. 4, # 8 p. 3883 - 3886
