7-溴-5-苯基-1,2-二氢-2H-1,4-苯并二氮杂卓-2-酮合成路线 （共 9 条）
反应条件
sulfuric acid; bromine in acetic acid T=20°C; 48 h;
参考文献
Yu, Shu; Ma, Chunrong; He, Xiaohui; McKernan, Ruth; Cook, James M.
Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 71 - 88
反应条件
water; sodium carbonate in ethanol 5 h; Heating / reflux;
参考文献
WISYS TECHNOLOGY FOUNDATION, INC.
Patent: US2006/3995 A1, 2006 ;
Location in patent: Page/Page column 48-49 ;
反应条件
1: With potassium carbonate in tetrahydrofuran T=0°C; 0.5 h; 2: With ammonium hydroxide; potassium carbonate in tetrahydrofuran T=20°C; 15 h; Further stages.;
参考文献
Safaei-Ghomi, Javad; Hatami, Alireza
Synthetic Communications, 2008 , vol. 38, # 2 p. 297 - 302
参考文献
COMMISSAR. A L'ENERG. ATOM. ET AUX ENERG. ALTERN.; INSTITUT CURIE; CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE
Patent: US2011/201601 A1, 2011 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; [HHMTA]Cl in methanol; water Heating; Yields of byproduct given;
参考文献
Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4777 - 4793
反应条件
[HHMTA]Cl in methanol; water Heating;
参考文献
Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4777 - 4793
反应条件
1: 90 percent / NH3 / methanol / Heating 2: 90 percent / Br2; H2SO4 / acetic acid / 48 h / 20 °C View Scheme
参考文献
Yu, Shu; Ma, Chunrong; He, Xiaohui; McKernan, Ruth; Cook, James M.
Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 71 - 88
反应条件
1: NaHCO3 / CH2Cl2 2: 90 percent / NH3 / methanol / Heating 3: 90 percent / Br2; H2SO4 / acetic acid / 48 h / 20 °C View Scheme
参考文献
Yu, Shu; Ma, Chunrong; He, Xiaohui; McKernan, Ruth; Cook, James M.
Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 71 - 88
参考文献
COMMISSAR. A L'ENERG. ATOM. ET AUX ENERG. ALTERN.; INSTITUT CURIE; CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE
Patent: US2011/201601 A1, 2011 ;
