2-氨基-5-乙基-1,3-噻唑-4-羧酸甲酯合成路线 （共 4 条）
反应条件
1: propionaldehyde; dichloroacetic acid ethyl ester With sodium methylate in diethyl ether 2: methanol; thiourea Heating;
参考文献
Cui, Yong-Mei; Huang, Qing-Qing; Xu, Jie; Chen, Ling-Ling; Li, Jing-Ya; Ye, Qi-Zhuang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3732 - 3736
反应条件
in methanol Heating;
参考文献
Takeda,A. et al.
Bulletin of the Chemical Society of Japan, 1970 , vol. 43, p. 2997 - 2998
反应条件
methanol; sodium 1.) Et2O, 0 deg C, 1 h, 2.) MeOH, reflux, 4 h; Multistep reaction;
参考文献
Barton, Anne; Breukelman, Stephen P.; Kaye, Perry T.; Meakins, G. Denis; Morgan, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 159 - 164
反应条件
sulfuric acid; copper(II) sulfate; sodium bromide; sodium nitrite in water
参考文献
ASAHI KASEI PHARMA CORPORATION
Patent: US2010/29690 A1, 2010 ;
Location in patent: Page/Page column 40 ;
US 20100029690 A1
