7-氯噻吩并[2,3-c]吡啶合成路线 （共 8 条）
反应条件
sodium carbonate in 1,4-dioxane; water; toluene
参考文献
Hoffmann-La Roche Inc.
Patent: US4735940 A1, 1988 ;
反应条件
trichlorophosphate Heating;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
trichlorophosphate in 1,4-dioxane 1) 10 min, 88 deg C, 2) 10 min, reflux;
参考文献
Fischer; Mohler; Schneider; Widmer
Helvetica Chimica Acta, 1990 , vol. 73, # 4 p. 763 - 781
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; chloroform / 0 °C / |Reflux 2.1: sodium azide / 1,4-dioxane; water / 0.5 h / 5 °C 2.2: 1 h / 240 °C 3.1: trichlorophosphate / 2.5 h / |Reflux View Scheme
参考文献
AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin
Patent: WO2013/173382 A1, 2013 ;
反应条件
1.1: sodium azide / 1,4-dioxane; water / 0.5 h / 5 °C 1.2: 1 h / 240 °C 2.1: trichlorophosphate / 2.5 h / |Reflux View Scheme
参考文献
AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin
Patent: WO2013/173382 A1, 2013 ;
反应条件
in ethanol T=120°C; 20 h;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
1: 59 percent / Ni(PPh3)2Cl2 / diethyl ether / 1.17 h
2: 84 percent / diethyl ether / 14.5 h / Ambient temperature
3: 100 percent / LiAlH4 / diethyl ether
View Scheme
参考文献
Knabe; Lorenz
Archiv der Pharmazie, 1983 , vol. 316, # 10 p. 831 - 834
反应条件
n-butyllithium in ethylene glycol dimethyl ether
1.) -35 deg C, 2.) 10 h, reflux;
参考文献
Knabe; Lorenz
Archiv der Pharmazie, 1983 , vol. 316, # 11 p. 912 - 915
