1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride in water T=0°C; 0.333333 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With sodium hydroxide; disodium hydrogenphosphate in water pH=1 - ~ 4.5; 2 h;
参考文献
THERAVANCE, INC.
Patent: US2006/135764 A1, 2006 ;
Location in patent: Page/Page column 22-23 ;
US 20060135764 A1
1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride; water T=70°C; 1 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With hydrogenchloride; sodium acetate in water T=0 - 20°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/84300 A1, 2008 ;
Location in patent: Page/Page column 100-101 ;
WO 2008/084300 A1
1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride in water T=0°C; 2: acetone-1,3-dicarboxylic acid; [14C]-N-Benzylamine hydrochloride With sodium acetate in water T=0 - 50°C; 3.66667 h; 3: With sodium hydroxide in water T=0°C; pH=10;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/9588 A1, 2004 ;
Location in patent: Page 63 ;
WO 2004/009588 A1
1: 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one With 2-chloroethoxycarbonyl chloride in chloroform T=20°C; 6 h; 2: With methanol in chloroform Heating / reflux; 3: benzyl bromide With potassium carbonate in 1-methyl-pyrrolidin-2-one T=20°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1726590 A1, 2006 ;
Location in patent: Page/Page column 55 ;
1: 2,3-dimethoxytetrahydrofuran With hydrogenchloride in water T=20°C; 0.333333 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With sodium acetate in water T=0 - 50°C; 3.08333 h; 3: With sodium hydrogencarbonate in diethyl ether; water pH=7;
