2-氯-N-甲氧基-N-甲基苯甲酰胺合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 20.1667 h;
参考文献
Wyeth
Patent: US2006/173049 A1, 2006 ;
Location in patent: Page/Page column 19 ;
US 20060173049 A1
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Hayashi, Yoshio; Yamazaki, Yuri; Sumikura, Makiko; Masuda, Yurika; Hayashi, Yoshiki; Yasui, Hiroyuki; Kiso, Yoshiaki; Chinen, Takumi; Usui, Takeo; Yakushiji, Fumika; Potts, Barbara; Neuteboom, Saskia; Palladino, Michael; Lloyd, George Kenneth
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4279 - 4289
反应条件
triethylamine; 1,1'-carbonyldiimidazole
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
反应条件
in tetrahydrofuran T=0°C; 1 h;
参考文献
N. V. ORGANON; DIJCKS, Fredricus Antonius; VEENEMAN, Gerrit Herman; PETERS, Johannes Lambertus Maria
Patent: WO2012/52395 A1, 2012 ;
Location in patent: Page/Page column 31 ;
WO 2012/052395 A1
反应条件
1: meta-dibromobenzene With iodine; magnesium in diethyl ether T=20 - 30°C; Inert atmosphere; 2: 2-chloro-N-methoxy-N-methylbenzamide in diethyl ether T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
1: 4-Methylpyridine With lithium diisopropyl amide in tetrahydrofuran; cyclohexane
T=-78 - 0°C; 0.5 h;
2: 2-chloro-N-methoxy-N-methylbenzamide in tetrahydrofuran; cyclohexane
T=-78 - 20°C;
参考文献
ALLERGAN, INC.
Patent: WO2009/91760 A1, 2009 ;
Location in patent: Page/Page column 41 ;
WO 2009/091760 A1
