1,3-二氢-5-苯基-1,4-苯并二氮杂卓-2-酮合成路线 （共 25 条）
反应条件
1: With sodium hydrogencarbonate in chloroform T=0°C; 2: With ammonia in methanol T=0 - 20°C; Heating / reflux;
参考文献
WiSys Technology Foundation, Inc.
Patent: US2006/258643 A1, 2006 ;
Location in patent: Page/Page column 27; sheet 3 ;
US 20060258643 A1
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in ethanol; chloroform
参考文献
Hoffmann-La Roche Inc.
Patent: US3996209 A1, 1976 ;
反应条件
ammonia in methanol Heating;
参考文献
Yu, Shu; Ma, Chunrong; He, Xiaohui; McKernan, Ruth; Cook, James M.
Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 71 - 88
参考文献
COMMISSAR. A L'ENERG. ATOM. ET AUX ENERG. ALTERN.; INSTITUT CURIE; CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE
Patent: US2011/201601 A1, 2011 ;
反应条件
ammonium acetate; acetic acid T=20°C;
参考文献
Spencer, John; Rathnam, Rajendra P.; Harvey, Alan L.; Clements, Carol J.; Clark, Rachel L.; Barrett, Michael P.; Wong, Pui Ee; Male, Louise; Coles, Simon J.; MacKay, Simon P.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1802 - 1815
反应条件
sodium iodide; ammonia; acetic acid in tetrahydrofuran; chloroform; ethyl acetate
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.; Japan Tobacco, Inc.
Patent: US5593988 A1, 1997 ;
反应条件
1: With dicyclohexyl-carbodiimide in toluene T=150°C; 0.5 h; Microwave irradiation; 2: With trifluoroacetic acid in toluene T=150°C; 0.333333 h; Microwave irradiation;
参考文献
Mwande-Maguene, Gabin; Jakhlal, Jouda; Lekana-Douki, Jean-Bernard; Mouray, Elisabeth; Bousquet, Till; Pellegrini, Sylvain; Grellier, Philippe; Ndouo, Fousseyni Samba Toure; Lebibi, Jacques; Pelinski, Lydie
New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2412 - 2415
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonia in ethanol T=70°C; Further byproducts given;
参考文献
Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4777 - 4793
反应条件
in pyridine Heating;
参考文献
Ley, Steven V.; Massi, Alessandro; Rodriguez, Felix; Horwell, David C.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Reid, Alison M.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 6 p. 1053 - 1055
反应条件
[HHMTA]Cl in methanol; water Heating;
参考文献
Clarke, George M.; Lee, J. Barry; Swinbourne, Frederick J.; Williamson, Basil
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4777 - 4793
