1,3-二氢-5-苯基-1,4-苯并二氮杂卓-2-酮合成路线 （共 25 条）
反应条件
1: BCl3; AlCl3 / 1,2-dichloro-ethane 2: pyridine View Scheme
参考文献
Pascal, Yves; Andrianjara, Charles R.; Auclair, Eric; Avenel, Nadine; Bertin, Bernadette; Calvet, Alain; Feru, Frederic; Lardon, Sophie; Moodley, Indres; Ouagued, Malika; Payne, Adrian; Pruniaux, Marie-Pierre; Szilagyi, Corinne
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 35 - 38
反应条件
1: BCl3; AlCl3 / 1,2-dichloro-ethane 2: pyridine View Scheme
参考文献
Pascal, Yves; Andrianjara, Charles R.; Auclair, Eric; Avenel, Nadine; Bertin, Bernadette; Calvet, Alain; Feru, Frederic; Lardon, Sophie; Moodley, Indres; Ouagued, Malika; Payne, Adrian; Pruniaux, Marie-Pierre; Szilagyi, Corinne
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 35 - 38
反应条件
pyridine Cyclocondensation;
参考文献
Pascal, Yves; Andrianjara, Charles R.; Auclair, Eric; Avenel, Nadine; Bertin, Bernadette; Calvet, Alain; Feru, Frederic; Lardon, Sophie; Moodley, Indres; Ouagued, Malika; Payne, Adrian; Pruniaux, Marie-Pierre; Szilagyi, Corinne
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 35 - 38
反应条件
1: 2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine With sodium hydride in N,N-dimethyl-formamide 1.5 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Spencer, John; Rathnam, Rajendra P.; Harvey, Alan L.; Clements, Carol J.; Clark, Rachel L.; Barrett, Michael P.; Wong, Pui Ee; Male, Louise; Coles, Simon J.; MacKay, Simon P.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1802 - 1815
反应条件
sodium hydroxide; Aliquatreg; 336 in toluene T=20 - 25°C; 4 h;
参考文献
Bock, Mark G.; DiPardo, Robert M.; Evans, Ben E.; Rittle, Kenneth E.; Veber, Daniel F.; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3232 - 3239
反应条件
sulfuric acid; bromine in acetic acid T=20°C; 48 h;
参考文献
Yu, Shu; Ma, Chunrong; He, Xiaohui; McKernan, Ruth; Cook, James M.
Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 71 - 88
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Guandalini; Balliu; Cellai; Martino; Nebbioso; Mercurio; Carafa; Bartolucci; Dei; Manetti; Teodori; Scapecchi; Altucci; Paoletti; Romanelli
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 56 - 68
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 18 h 2: 3 h / 70 °C 3: 900 mg / aq. NaOH / methanol / 2 h View Scheme
参考文献
Carter, Malcolm C.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Jo; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Henderson, Elisa A.; Keegan, Sally J.; Kelsey, Richard D.; Lockyer, Michael J.; Stables, Jeremy N.; Wilson, Lara J.; Powell, Kenneth L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2311 - 2319
反应条件
1: 93 percent / Aliquat 336, 50percent aq. NaOH / toluene / 4 h / 20 - 25 °C 2: 81.6 percent / t-BuOK, isoamyl nitrite / toluene / 0.5 h / -20 - 0 °C View Scheme
参考文献
Bock, Mark G.; DiPardo, Robert M.; Evans, Ben E.; Rittle, Kenneth E.; Veber, Daniel F.; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3232 - 3239
反应条件
n-butyllithium; tetraphosphorus decasulfide in tetrahydrofuran; hexane 16 h; Heating;
参考文献
Goel, O. P.; Krolls, U.
Synthesis, 1987 , # 2 p. 162 - 164
