噻吩并[2,3-c]吡啶-7(6h)-酮合成路线 （共 6 条）
反应条件
1: 74 percent / POCl3 / Heating 2: 60 percent / ethanol / 20 h / 120 °C View Scheme
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
trichlorophosphate Heating;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
tributyl-amine; triethylamine in diphenylether; water; acetone
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US6034093 A1, 2000 ;
US 6034093 A
反应条件
copper in quinoline
T=200 - 210°C; 2 h;
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
copper in quinoline
T=200 - 210°C; 1 h;
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
1: With triethylamine in acetone
Cooling with ice;
2: With sodium azide in water; acetone
1 h; Cooling with ice;
3: With tributyl-amine; diphenylamine
T=220°C; 1.5 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
