4-氟-2-异丙氧基硝基苯合成路线 （共 5 条）
反应条件
potassium carbonate in acetone Reflux;
参考文献
RIGEL PHARMACEUTICALS, INC.; SINGH, Rajinder; DUNCTON, Matthew; ZHANG, Jing; ALVAREZ, Salvador; TSO, Kin; HOLLAND, Sacha; YEN, Rose; KOLLURI, Rao; HECKRODT, Thilo; CHEN, Yan; MASUDA, Esteban; LI, Hui; PAYAN, Donald G.; KELLEY, Ryan
Patent: WO2013/152198 A1, 2013 ;
Location in patent: Paragraph 00587 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 20°C;
参考文献
H. LUNDBECK A/S
Patent: WO2004/82677 A1, 2004 ;
Location in patent: Page/Page column 108 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Reitz, Allen B.; McDonnell, Mark E.; Baxter, Ellen W.; Codd, Ellen E.; Wu, Wu-Nan
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 14 p. 1927 - 1930
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
反应条件
in ammonia T=-70°C; 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kizner, T. A.; Shteingarts, V. D.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382
