4-苄氧基-3-羟基苯乙酸合成路线 （共 6 条）
反应条件
water; copper; copper(II) oxide; potassium hydroxide T=140°C; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1: acetic acid; bromine / 2 h / 20 °C 2: potassium carbonate / acetone / |Reflux 3: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; LIU, Hong; XIE, Xin; ZHEN, Xuechu; SUN, Haifeng; LI, Jing; ZHU, Liyuan; LI, Zeng; CHEN, Ying; JIANG, Hualiang; CHEN, Kaixian
Patent: US2014/88130 A1, 2014 ;
反应条件
1: potassium carbonate / acetone / |Reflux 2: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; LIU, Hong; XIE, Xin; ZHEN, Xuechu; SUN, Haifeng; LI, Jing; ZHU, Liyuan; LI, Zeng; CHEN, Ying; JIANG, Hualiang; CHEN, Kaixian
Patent: US2014/88130 A1, 2014 ;
反应条件
1.1: 3,4,5-trimethoxyphenylboronic acid / toluene / 1 h / |Reflux; |Dean-Stark 1.2: 46 h / 100 °C / |Molecular sieve; |Sealed tube 1.3: 2 h / |Reflux 2.1: potassium carbonate / acetone / 4 h / |Reflux 3.1: ethanol / 14 h / |Reflux 4.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 5.1: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 6.1: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 7.1: water; sodium hydroxide / ethanol / 3 h / 20 °C 8.1: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 9.1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 10.1: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1.1: 3,4,5-trimethoxyphenylboronic acid / toluene / 1 h / |Reflux; |Dean-Stark 1.2: 46 h / 100 °C / |Molecular sieve; |Sealed tube 1.3: 2 h / |Reflux 2.1: potassium carbonate / acetone / 4 h / |Reflux 3.1: ethanol / 14 h / |Reflux 4.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 5.1: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 6.1: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 7.1: water; sodium hydroxide / ethanol / 3 h / 20 °C 8.1: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 9.1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 10.1: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1: 2-(4-(benzyloxy)-3-hydroxyphenyl)acetic acid With 3,4,5-trimethoxyphenylboronic acid in toluene
1 h; RefluxDean-Stark;
2: formaldehyd in toluene
T=100°C; 46 h; Molecular sieveSealed tube;
3: in water
2 h; Reflux;
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
