3-氯-5-苯基异噻唑-4-甲腈合成路线 （共 8 条）
反应条件
18-crown-6 ether; potassium carbonate; palladium diacetate in toluene T=110°C; Suzuki coupling; 2 h;
参考文献
Christoforou, Irene C.; Koutentis, Panayiotis A.; Rees, Charles W.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 16 p. 2900 - 2907
反应条件
potassium fluoride; 18-crown-6 ether; palladium diacetate in toluene T=110°C; Suzuki coupling; 3 h;
参考文献
Christoforou, Irene C.; Koutentis, Panayiotis A.; Rees, Charles W.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 16 p. 2900 - 2907
反应条件
PdCl2(PPh3)2; silver fluoride; triphenylphosphine in acetonitrile T=20 - 82°C; 0.416667 h;
参考文献
Ioannidou, Heraklidia A.; Koutentis, Panayiotis A.
Organic Letters, 2011 , vol. 13, # 6 p. 1510 - 1513
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=60°C; Negishi coupling;
参考文献
Christoforou, Irene C.; Koutentis, Panayiotis A.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 19 p. 3681 - 3693
反应条件
palladium diacetate in N,N-dimethyl-formamide T=20 - 100°C; Stille coupling; 23 h;
参考文献
Christoforou, Irene C.; Koutentis, Panayiotis A.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 19 p. 3681 - 3693
反应条件
pyridine; disulfur dichloride T=140 - 150°C; Cyclization;
参考文献
Cutri, Christian C. C.; Garozzo, Adriana; Siracusa, Maria A.; Sarva, Maria C.; Tempera, Gianna; Geremia, Ernesto; Pinizzotto, Maria R.; Guerrera, Francesco
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2271 - 2280
参考文献
Christoforou, Irene C.; Koutentis, Panayiotis A.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 19 p. 3681 - 3693
反应条件
sulfuric acid
T=20 - 100°C; 2.66667 h;
参考文献
Christoforou, Irene C.; Koutentis, Panayiotis A.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1381 - 1390
