N-苄氧羰基-N-甲基-L-苯丙氨酸合成路线 （共 14 条）
反应条件
1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 20 °C 2.1: triethylamine / dichloromethane / 3 h / 0 °C 3.1: (+)-(2S)-2-(3-ethylbenzyl)-2,3-dimethylimidazolidin-4-one; 2,6-lutidinium trifluoromethanesulfonate; 2,6-dimethylpyridine / dimethyl sulfoxide; acetonitrile / 16 h 3.2: 3 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 31 p. 11521 - 11524
反应条件
1: With 2,6-dimethylpyridine; 2,6-lutidinium trifluoromethanesulfonate; (+)-(2S)-2-(3-ethylbenzyl)-2,3-dimethylimidazolidin-4-one in dimethyl sulfoxide; acetonitrile 16 h; 2: With potassium permanganate; sodium dihydrogenphosphate in water; tert-butyl alcohol 3 h; Overall yield = 22 mg;
参考文献
Journal of the American Chemical Society, , vol. 135, # 31 p. 11521 - 11524
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol 1.5 h;
参考文献
Hanessian, Stephen; Jennequin, Thomas; Boyer, Nicolas; Babonneau, Vincent; Soma, Udaykumar; Mannoury La Cour, Clotilde; Millan, Mark J.; De Nanteuil, Guillaume
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 5 p. 550 - 555
反应条件
1: (i) Et3N, ClCO2Et, THF, (ii) NH3 2: H2 / Pd-C / acetic acid View Scheme
参考文献
Gregory; Jones; Morley
Journal of the Chemical Society. Perkin transactions 1, 1968 , vol. 5, p. 531 - 540
