5-氧代-L-脯氨酸五氯苯基酯合成路线 （共 6 条）
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran 1.) 0 deg C, 1 h, 2.) r.t., overnight;
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. B.; Trofimov, S. S.; Kosoi, M. Yu.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 191 - 194
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 271 - 275
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
Gudasheva, T. A.; Rozantsev, G. G.; Ostrovskaya, R. U.; Trofimov, S. S.; Voronina, T. A.; et al.
Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 1 p. 14 - 17
Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 1 p. 15 - 18
反应条件
n-ethyl morpholine in N,N-dimethyl-formamide T=20°C;
参考文献
Gudasheva; Trofimov; Morozova; Nikitin; Ostrovskaya; Voronina; Seredenin
Pharmaceutical Chemistry Journal, 2006 , vol. 40, # 1 p. 18 - 22
反应条件
1: Et3N / dimethylformamide / 5 h / Ambient temperature 2: 83 percent / NH3 / methanol / Ambient temperature View Scheme
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. B.; Trofimov, S. S.; Kosoi, M. Yu.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 191 - 194
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 271 - 275
反应条件
triethylamine in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Magni; Signorelli; Bocchiola
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 12 A p. 1402 - 1404
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
