1-苯基丁-2-炔-1,4-二醇合成路线 （共 12 条）
反应条件
1: propargyl alcohol With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: benzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere;
参考文献
Grigorjeva, Liene; Jirgensons, Aigars
European Journal of Organic Chemistry, 2011 , # 13 p. 2421 - 2425
反应条件
1: 2-(2-propynyloxy)-tetrahydro-2H-pyran With methyl-magnesium chloride in THF-d8 (tetrahydrofuran-d8) T=0°C; Schlenk techniqueInert atmosphere; 2: benzaldehyde in tetrahydrofuran T=0 - 20°C; Schlenk techniqueInert atmosphere; Further stages;
参考文献
Hazra, Chinmoy K.; Irran, Elisabeth; Oestreich, Martin
European Journal of Organic Chemistry, 2013 , # 22 p. 4903 - 4908
反应条件
pyridinium p-toluenesulfonate in methanol T=55°C; 3 h;
参考文献
Duffy, Michael G.; Grayson, David H.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 13 p. 1555 - 1563
反应条件
aniline; (π-allyl)palladium triflate based catalyst T=50°C; 24 h;
参考文献
Murakami, Hiromi; Minami, Tatsuya; Ozawa, Fumiyuki
Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4482 - 4486
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Boeckman Jr.; Thomas
Journal of the American Chemical Society, 1979 , vol. 101, # 4 p. 987 - 994
反应条件
1: tetrahydrofuran / 0 °C 2: TBAF View Scheme
参考文献
Gharibyan; Makaryan; Hovhannisyan; Kinoyan; Chobanyan
Russian Journal of General Chemistry, 2014 , vol. 84, # 3 p. 457 - 464
Zh. Obshch. Khim., 2014 , vol. 84, # 3 p. 399 - 406,8
反应条件
diethyl ether anschliessend Behandeln mit Benzaldehyd;
参考文献
Gouge
Annales de Chimie (Cachan, France), 1951 , vol. <12> 6, p. 648,682
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Fiesselmann; Sasse
Chemische Berichte, 1956 , vol. 89, p. 1775,1788
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Armitage et al.
Journal of the Chemical Society, 1954 , p. 147,153
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Franzen
Chemische Berichte, 1955 , vol. 88, p. 717,720, 723
反应条件
tetrabutyl ammonium fluoride
参考文献
Kondo, Kazuhiro; Kazuta, Kumiko; Saitoh, Atsushi; Murakami, Yasuoki
Heterocycles, 2003 , vol. 59, # 1 p. 97 - 100
反应条件
benzoic acid; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene T=110°C; 24 h; Title compound not separated from byproducts.;
参考文献
Tetrahedron Letters, , vol. 48, # 29 p. 5111 - 5114
反应条件
ruthenium(II)-carbonyl-tris(triphenylphosphine) dihydride; acetic acid; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene 24 h; Inert atmosphereReflux;
参考文献
Tetrahedron, , vol. 65, # 44 p. 8981 - 8986
