N-甲基-1-[3,5-(双三氟甲基)苯基]乙胺合成路线 （共 5 条）
反应条件
1: With sodium tris(acetoxy)borohydride in tetrahydrofuran; 1,2-dichloro-ethane T=20°C; 3 h; 2: With sodium hydrogencarbonate in water
参考文献
WO2005/821 A1, ;
Page 30 ;
WO 2005/000821 A1
反应条件
sodium tetrahydroborate in methanol
参考文献
Organic Process Research and Development, , vol. 13, # 6 p. 1100 - 1110
反应条件
1: methanol 2: sodium tetrahydroborate / methanol View Scheme
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1188 - 1194
反应条件
1: With (+)-(R)-malic acid in ethyl acetate T=0°C; 5.83333 h; Resolution of racemate; 2: With sodium hydroxide in water
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/110996 A1, 2004 ;
Location in patent: Page/Page column 25 ;
WO 2004/110996 A1
反应条件
in ethyl acetate; isopropyl alcohol; toluene
T=4 - 75°C; 8.5 h;
参考文献
AVECIA PHARMACEUTICALS LIMITED
Patent: WO2006/67395 A1, 2006 ;
Location in patent: Page/Page column 23-24 ;
