N-叔丁氧基羰基-5-甲氧基-2-吲哚硼酸合成路线 （共 6 条）
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran T=0°C; 2 h; 2: With phosphate buffer in tetrahydrofuran pH=6.0; Further stages.;
参考文献
Mizuta, Masahiro; Seio, Kohji; Miyata, Kenichi; Sekine, Mitsuo
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5046 - 5055
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=0°C; 1.16667 h; 2: With hydrogenchloride; water in tetrahydrofuran; hexanes
参考文献
NOVARTIS AG; ATKINSON, Benjamin; BEATTIE, David; CULSHAW, Andrew James; DALE, James; DEVEREUX, Nicholas James; MCKENNA, Jeffrey
Patent: WO2011/92293 A2, 2011 ;
Location in patent: Page/Page column 86 ;
WO 2011/092293 A1
反应条件
1.1: 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 1 h / 20 °C 2.1: triisopropyl borate; LDA / tetrahydrofuran / 2 h / 0 °C 2.2: 96 percent / aq. phosphate buffer / tetrahydrofuran / pH 6.0 View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 11 p. 1705 - 1713
反应条件
1.1: 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 1 h / 20 °C 2.1: triisopropyl borate; LDA / tetrahydrofuran / 2 h / 0 °C 2.2: 96 percent / aq. phosphate buffer / tetrahydrofuran / pH 6.0 View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 11 p. 1705 - 1713
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; caesium carbonate in toluene T=110°C; 12 h; Inert atmosphere;
参考文献
Chemical Communications, , vol. 48, # 2 p. 203 - 205
反应条件
1: sodium hydrogencarbonate; sodium hydroxide; Oxonereg; / water; tetrahydrofuran; acetone / 0.5 h / 0 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
NOVARTIS AG; ATKINSON, Benjamin; BEATTIE, David; CULSHAW, Andrew James; DALE, James; DEVEREUX, Nicholas James; MCKENNA, Jeffrey
Patent: WO2011/92293 A2, 2011 ;
WO 2011/092293 A1
