sodium hydroxide in tetrahydrofuran T=25°C; Hydrolysis; 6 h;

1.1: 95 percent / NaOH 6N / tetrahydrofuran / 6 h / 25 °C 2.1: TEA / acetone / 0 °C 2.2: 95 percent / NaN3 / acetone / 0 °C 3.1: 95 percent / 0.17 h / 115 °C 4.1: 95 percent / NaOMe / methanol / 25 °C 5.1: 95 percent / KOH 6N / 1,2-dimethoxy-ethane / 12 h / reflux View Scheme