1: 1.) (Bn3Sn)2O / 1.) toluene, reflux, 2 h; 2.) 20 deg C, 16 h 2: 96 percent / sodium hydride / dimethylformamide / 16 h / 20 °C 3: 60 percent / H2SO4 / acetic acid / 1.5 h / 0 °C 4: 98.9 percent / HCl / CH2Cl2 / 48 h / 20 °C 5: 1.) AgSO3CF3, Me2NCONMe2; 2.) NaOMe / 1.) CH2Cl2, 20 deg C, 16 h; 2.) MeOH, 20 deg C, 16 h View Scheme

sodium hydride

sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C; 48 h;

sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere;

1: 1.) (Bn3Sn)2O / 1.) toluene, reflux, 2 h; 2.) 20 deg C, 16 h 2: 96 percent / sodium hydride / dimethylformamide / 16 h / 20 °C 3: 60 percent / H2SO4 / acetic acid / 1.5 h / 0 °C View Scheme