7,3',4'-三-O-甲基毛地黄黄酮合成路线 （共 33 条）
反应条件
potassium carbonate in acetone 2 h; Heating;
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
反应条件
1: 97 percent / K2CO3 / acetone / 2 h / Heating 2: 86 percent / dimethyl dioxirane / acetone; CH2Cl2 / 0.5 h / 0 - 20 °C 3: 83 percent / BBr3 / CH2Cl2 / 6 h / Heating View Scheme
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
参考文献
Journal of the Chemical Society, , vol. 77, p. 1317
反应条件
1: 93 percent / dimethyl dioxirane / acetone; CH2Cl2 / 0.33 h / 0 - 20 °C 2: 41 percent / K2CO3 / acetone / 1 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 11 p. 2647 - 2655
参考文献
Perkin; Horsfall
Journal of the Chemical Society, 1900 , vol. 77, p. 1317
反应条件
1: 97 percent / K2CO3 / acetone / 2 h / Heating 2: 86 percent / dimethyl dioxirane / acetone; CH2Cl2 / 0.5 h / 0 - 20 °C 3: 96 percent / K2CO3 / acetone / 1 h / Heating 4: 99 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 11 p. 2647 - 2655
反应条件
boron tribromide in dichloromethane
T=0 - 20°C;
参考文献
AxoGlia Therapeutics S.A.
Patent: EP2112145 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
potassium hydroxide in methanol
6 h;
参考文献
Miles, Christopher O.; Main, Lyndsay
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1623 - 1632
反应条件
in methanol; diethyl ether
T=20°C; 1 h;
参考文献
Matsuda, Hisashi; Morikawa, Toshio; Toguchida, Iwao; Yoshikawa, Masayuki
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 6 p. 788 - 795
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
