二甲基-2-(2-硝基-4-三氟甲基苯基)丙二酸合成路线 （共 7 条）
反应条件
potassium tert-butylate in tert-butyl alcohol 3 - 6 h; Heating / reflux;
参考文献
US2006/47126 A1, ;
Page/Page column 26 ;
反应条件
1: oxalic acid diethyl ester With sodium hydride in dimethyl sulfoxide T=100°C; 1 h; 2: 2-methyl-5-trifluoromethylnitrobenzene in dimethyl sulfoxide T=20 - 100°C; 1.5 h;
参考文献
US6878733 B1, ;
Page/Page column 171 ;
US 6878733 B1
反应条件
1: malonic acid dimethyl ester With sodium hydride in dimethyl sulfoxide T=100°C; 1 h; 2: 1-fluoro-2-nitro-4-trifluoromethylbenzene in dimethyl sulfoxide T=20 - 100°C; 1 h;
参考文献
WO2007/106564 A2, ;
Page/Page column 49-50 ;
反应条件
in hexane; dimethyl sulfoxide; ethyl acetate
参考文献
US6486185 B1, ;
US 6486185 B1
反应条件
sodium chloride in water; dimethyl sulfoxide T=120°C; 16 - 20 h;
参考文献
Georg, Gunda I.; Tash, Joseph S.; Chakrasali, Ramappa; Jakkaraj, Sudhakar Rao
Patent: US2006/47126 A1, 2006 ;
Location in patent: Page/Page column 26 ;
反应条件
1: With hydrogenchloride; water Heating / reflux; 2:
参考文献
LIGAND PHARMACEUTICALS INC.
Patent: WO2007/106564 A2, 2007 ;
Location in patent: Page/Page column 49-50 ;
反应条件
1: dimethyl sulfoxide; sodium chloride / water / 120 °C
2: hydrogen / 5 Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
3: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
View Scheme
参考文献
UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.
Patent: WO2011/5759 A2, 2011 ;
