2,4-二氯-3,5-二硝基三氟甲苯合成路线 (共 12 条)
反应条件
sulfuric acid; nitric acid in water T=80°C; 96 h;
参考文献
Hori, Hitoshi; Noguchi, Naoto; Yokoyama, Hideakira; Ise, Hirohiko; Jin, Cheng-Zhe; Kasai, Soko; Goto, Takatsugu; Taira, Zenei
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 247 - 253
反应条件
sulfur trioxide; nitric acid in water
参考文献
Montedison S.p.A.
Patent: US4110405 A1, 1978 ;
参考文献
United States Borax and Chemical Corporation
Patent: US3966816 A1, 1976 ;
反应条件
in ethanol T=95 - 100°C; 72 h; Sealed flask;
参考文献
Endeshaw, Molla M.; Li, Catherine; Leon, Jessica De; Yao, Ni; Latibeaudiere, Kirk; Premalatha, Kokku; Morrissette, Naomi; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5179 - 5183
反应条件
(i) EtOH, (ii) NH3; Multistep reaction;
参考文献
US Borax
Patent: DE2013509 , 1970 ;
Chem.Abstr., 1970 , vol. 73, # 120287
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US Borax and Chem. Corp.
Patent: US3903078 , 1975 ;
Chem.Abstr., 1976 , vol. 84, # 43581
反应条件
potassium hydroxide in methyl isobutyl ketone (MIBK) T=25 - 30°C; Product distribution / selectivity;
参考文献
MAKHTESHIM CHEMICAL WORKS LTD.
Patent: WO2007/60662 A2, 2007 ;
Location in patent: Page/Page column 25-27 ;
反应条件
in ethanol T=100°C; 72 h; Sealed flask;
参考文献
Endeshaw, Molla M.; Li, Catherine; Leon, Jessica De; Yao, Ni; Latibeaudiere, Kirk; Premalatha, Kokku; Morrissette, Naomi; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5179 - 5183
参考文献
Eli Lilly and Company
Patent: US4152460 A1, 1979 ;
参考文献
Eli Lilly and Company
Patent: US4152460 A1, 1979 ;
反应条件
potassium carbonate in methanol; acetone
参考文献
GAF Corporation
Patent: US4086364 A1, 1978 ;