4-喹唑啉酮-2-甲酸乙酯合成路线 （共 14 条）
反应条件
hydrazine hydrate in butan-1-ol 6 h; Heating;
参考文献
Amine, M S; El-Hashash, M A; Attia, I A
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 5 p. 577 - 580
反应条件
1: H2O
2: 86 percent / triethylamine / tetrahydrofuran / 3 h
3: 73 percent / diethyl ether
4: 4-methylpiperidine / benzene / Ambient temperature
View Scheme
参考文献
Rastogi, Rashmi; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 8 p. 744 - 746
反应条件
ammonium hydroxide
T=70°C; 2 h;
参考文献
Varadi, Andras; Horvath, Peter; Kurtan, Tibor; Mandi, Attila; Toth, Gerg; Gergely, Andras; Koekoesi, Jozsef
Tetrahedron, 2012 , vol. 68, # 50 p. 10365 - 10371
反应条件
1.1: N,N-dimethyl-formamide; thionyl chloride / chloroform / 4.5 h / |Reflux
2.1: triethylamine; palladium 10 on activated carbon; hydrogen / ethanol / 4 h / 20 °C / 775.74 Torr
2.2: 3 h / |Reflux
View Scheme
参考文献
Yuan, Yunyun; Elbegdorj, Orgil; Beletskaya, Irina O.; Selley, Dana E.; Zhang, Yan
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5045 - 5048
