乙基2-甲基-5-苯基-3-糠酸酯合成路线 （共 16 条）
反应条件
1: 1.) sodium pellets / 1.) toluene, room temp., 3 days, 2.) toluene, 0 deg C, 1 h then room temp., 1 day 2: 72 percent / 12 M hydrochloric acid / ethanol / 24 h / Heating View Scheme
参考文献
Porretta; Scalzo; Chimenti; Bolasco; Biava; Fischetti; Riccardi
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 5 p. 629 - 639
反应条件
1: 1.) sodium pellets / 1.) toluene, room temp., 3 days, 2.) toluene, 0 deg C, 1 h then room temp., 1 day 2: 72 percent / 12 M hydrochloric acid / ethanol / 24 h / Heating View Scheme
参考文献
Porretta; Scalzo; Chimenti; Bolasco; Biava; Fischetti; Riccardi
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 5 p. 629 - 639
参考文献
Paal
Chemische Berichte, 1884 , vol. 17, p. 2766
Chemische Berichte, 1885 , vol. 18, p. 58
Full Text Show Details
Weltner
Chemische Berichte, 1884 , vol. 17, p. 72
Chemische Berichte, 1885 , vol. 18, p. 790
反应条件
ethanol 1.) -75 deg C, 2 h, 2.) RT, 40 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hirao, Toshikazu; Fujii, Takashi; Ohshiro, Yoshiki
Journal of Organometallic Chemistry, 1991 , vol. 407, # 1 p. C1 - C4
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2: With hydrogenchloride; water in tetrahydrofuran Product distribution / selectivity;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2210876 A1, 2010 ;
Location in patent: Page/Page column 113 ;
反应条件
sodium in ethanol 3 h; Heating;
参考文献
Farmaco, Edizione Scientifica, , vol. 42, # 5 p. 629 - 639
