DL-2-氯-2-苯基乙酰氯合成路线 （共 51 条）
参考文献
Miller; Johnson
Journal of Organic Chemistry, 1936 , vol. 1, p. 135,136, 139
参考文献
Miller; Johnson
Journal of Organic Chemistry, 1936 , vol. 1, p. 135,136, 139
反应条件
in diethyl ether
T=0°C;
参考文献
Moderhack, Dietrich; Lorke, Michael; Schomburg, Dietmar
Liebigs Annalen der Chemie, 1984 , # 10 p. 1685 - 1695
反应条件
sodium methylate; triethylamine
1) CH2Cl2, 3 h; 2) 18 h; Yield given. Multistep reaction;
参考文献
Weintraub; Skoog; Nichols; Wiseman; Huber; Baugh; Farrell
Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 11 p. 937 - 943
反应条件
1: 80 percent / triethylamine / hexane / 4 h / Heating
2: NaBH4 / propan-2-ol / Ambient temperature
3: 100 percent / 18percent methanolic HCl / 5 h / Heating
View Scheme
参考文献
Brady, William T.; Watts, Ronald D.
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3525 - 3527
反应条件
1: 78 percent / 10percent aq. NaOH / diethyl ether / 0 deg C, 1 h, then r.t., 1.5 h
2: 1) NaH / 1) oil, THF, 0 deg C, 2) THF, 6 h, reflux
3: 93 percent / a) bromine, triphenylphosphine, b) Et3N / CH2Cl2 / a) 0.5 h, r.t., b) 12 h, r.t.
View Scheme
参考文献
Aoyama; Nakano; Marumo; Uno; Shioiri
Synthesis, 1991 , # 12 p. 1163 - 1167
反应条件
1: 78 percent / 10percent aq. NaOH / diethyl ether / 0 deg C, 1 h, then r.t., 1.5 h
2: 1) NaH / 1) oil, THF, 0 deg C, 2) THF, 6 h, reflux
View Scheme
参考文献
Aoyama; Nakano; Marumo; Uno; Shioiri
Synthesis, 1991 , # 12 p. 1163 - 1167
反应条件
aluminium trichloride
T=30 - 65°C;
参考文献
Fuson et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 1464
参考文献
Fuson et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 1464
反应条件
triethylamine in hexane
2.5 h; Heating;
参考文献
Brady, William T.; Agho, Michael O.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5337 - 5341
