N-(4-溴-2-三氟甲基苯基)乙酰胺合成路线 （共 6 条）
反应条件
in chloroform T=0 - 20°C;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 158 ;
反应条件
in tetrahydrofuran T=0 - 25°C; 2.16667 h;
参考文献
Hoffmann-La Roche Inc.
Patent: US6369232 B1, 2002 ;
Location in patent: Page column 57 ;
反应条件
acetic anhydride in tetrahydrofuran
参考文献
Sidduri, Achyutharao
Patent: US2002/35266 A1, 2002 ;
反应条件
copper diacetate; palladium diacetate; 2,2,2-trimethylacetic acid in 1,2-dichloro-ethane T=110°C; 24 h; Inert atmosphereSchlenk techniqueSealed tubeGreen chemistry;
参考文献
Zhang, Li-Sheng; Chen, Kang; Chen, Guihua; Li, Bi-Jie; Luo, Shuang; Guo, Qing-Yun; Wei, Jiang-Bo; Shi, Zhang-Jie
Organic Letters, 2013 , vol. 15, # 1 p. 10 - 13
反应条件
1: concd. H2SO4, concd. HNO3 / 0 - 20 °C 2: concd. HCl / Heating 3: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
反应条件
1: With nitric acid; sulfuric acid T=5 - 12°C; 2: With hydrogenchloride in methanol; water T=100°C;
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth
Patent: WO2011/97491 A1, 2011 ;
Location in patent: Page/Page column 117-118 ;
