(R)-1-(3-氯苯基)-2-羟基-1-丙酮合成路线 （共 2 条）
反应条件
1: (R)-(+)-1-(3-chlorophenyl)-2-hydroxypropan-1-one With trifluoromethylsulfonic anhydride; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in dichloromethane T=-50 - 0°C; 1 h; 2: 2-amino-2-methyl-propan-1-ol in dichloromethane; acetonitrile T=-10 - 0°C; 4 h;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, F. Ivy; BLOUGH, Bruce E.; NAVARRO, Hernan A.; MASCARELLA, S. Wayne; MURESAN, Ana Zamfira; DAMAJ, M. Imad; LUKAS, Ronald J.
Patent: WO2011/146821 A2, 2011 ;
Location in patent: Page/Page column 54 ;
WO 2011/146821 A2
反应条件
1: lutidine / CH2Cl2 / -40 °C 2: CH2Cl2 / -40 - 0 °C View Scheme
参考文献
Fang, Qun K.; Han, Zhengxu; Grover, Paul; Kessler, Donald; Senanayake, Chris H.; Wald, Stephen A.
Tetrahedron Asymmetry, 2000 , vol. 11, # 18 p. 3659 - 3663
