(S)-(-)-3-丁炔-2-醇合成路线 （共 18 条）
参考文献
AVECIA PHARMACEUTICALS LIMITED
Patent: WO2005/108346 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
tetrabutyl ammonium fluoride
参考文献
Thompson; Jamison; Jacobsen
Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 9974 - 9983
反应条件
sodium hydroxide in water 2 h; Ambient temperature;
参考文献
Cotterill, Ann S.; Gill, Melvyn; Gimenez, Alberto; Milanovic Nives M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 22 p. 3269 - 3276
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C;
参考文献
Arai, Noriyoshi; Satoh, Hironori; Utsumi, Noriyuki; Murata, Kunihiko; Tsutsumi, Kunihiko; Ohkuma, Takeshi
Organic Letters, 2013 , vol. 15, # 12 p. 3030 - 3033
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C;
参考文献
Arai, Noriyoshi; Satoh, Hironori; Utsumi, Noriyuki; Murata, Kunihiko; Tsutsumi, Kunihiko; Ohkuma, Takeshi
Organic Letters, 2013 , vol. 15, # 12 p. 3030 - 3033
反应条件
n-butyllithium in tetrahydrofuran T=-70 - -60°C; 1.16667 h;
参考文献
Kolasa, Teodozyj; Stewart, Andrew O.; Brooks, Clint D. W.
Tetrahedron Asymmetry, 1996 , vol. 7, # 3 p. 729 - 736
反应条件
isopropyl alcohol in water 24 h; Microbiological reactionEnzymatic reaction; enantioselective reaction;
参考文献
Cuetos, Anibal; Bisogno, Fabricio R.; Lavandera, Ivan; Gotor, Vicente
Chemical Communications, 2013 , vol. 49, # 26 p. 2625 - 2627
反应条件
sodium hydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Kusuda, Shinya; Kawamura, Kiyoshi; Ueno, Yoshio; Toru, Takeshi
Tetrahedron Letters, 1993 , vol. 34, # 41 p. 6587 - 6590
反应条件
1: With pyridine in dichloromethane 2: With Ps. fluorescens I hydrolase in phosphate buffer T=37°C; pH=7.3; 2.5 h; Title compound not separated from byproducts;
参考文献
Baumann, Markus; Hauer, Bernhard H.; Bornscheuer, Uwe T.
Tetrahedron Asymmetry, 2000 , vol. 11, # 23 p. 4781 - 4790
反应条件
sodium phosphate buffer; esterase B from Candida antarctica in water T=37°C; pH=7.3; 1 h; Product distribution;
参考文献
Baumann, Markus; Stuermer, Rainer; Bornscheuer, Uwe T.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 22 p. 4201 - 4204
