(S)-3,4,5,6,7,8-六氢-1-[(4-甲氧基苯基)甲基](1H)-异喹啉-2-甲醛合成路线 （共 15 条）
参考文献
Passarotti; Valenti; Grianti
Bollettino Chimico Farmaceutico, 1993 , vol. 132, # 11 p. 475 - 477
反应条件
1: superphosphoric acid / 360 h / 50 °C 2: 3.2 g / 48percent aq. HBr / 5 h / Heating View Scheme
参考文献
Passarotti; Valenti; Grianti
Bollettino Chimico Farmaceutico, 1993 , vol. 132, # 11 p. 475 - 477
反应条件
1: superphosphoric acid / 360 h / 50 °C 2: 3.2 g / 48percent aq. HBr / 5 h / Heating 3: 1.) formic acid, 2.) 1 N methanolic NaOH / 1.) H2O, reflux, 5 h, 2.) reflux, 2 h View Scheme
参考文献
Passarotti; Valenti; Grianti
Bollettino Chimico Farmaceutico, 1993 , vol. 132, # 11 p. 475 - 477
参考文献
Kitamura, M.; Hsiao, Yi; Noyori, R.; Takaya, H.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4829 - 4832
反应条件
lt;Ru(OAc)2((S)-(6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine))gt;; hydrogen in methanol
T=100°C; P=45003.6 Torr; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Heiser; Broger; Crameri
Tetrahedron Asymmetry, 1991 , vol. 2, # 1 p. 51 - 62
反应条件
hydrogen; Ru(OCOCF3)2((S)-tolbinap) in methanol
T=30°C; P=76000.1 Torr; 100 h;
参考文献
Kitamura, M.; Hsiao, Yi; Noyori, R.; Takaya, H.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4829 - 4832
参考文献
Meyers; Bailey
Journal of Organic Chemistry, 1986 , vol. 51, # 6 p. 872 - 875
反应条件
1: pyridine / tetrahydrofuran / 8 h / 0 °C
2: H2 / Ru(CF3COO)2<(R)-TolBINAP> / methanol / 164 h / 30 °C / 76000 Torr
View Scheme
参考文献
Kitamura; Hsiao; Ohta; Tsukamoto; Takaya; Noyori
Journal of Organic Chemistry, 1994 , vol. 59, # 2 p. 297 - 310
反应条件
1: 5 h / 150 °C
2: POCl3 / benzene / Heating
3: pyridine; tetrahydrofuran / 8 h / 0 °C
4: H2 / Ru(OCOCF3)2<(S)-tolbinap> / methanol / 100 h / 30 °C / 76000.1 Torr
View Scheme
参考文献
Kitamura, M.; Hsiao, Yi; Noyori, R.; Takaya, H.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4829 - 4832
反应条件
1: POCl3 / benzene / Heating
2: pyridine; tetrahydrofuran / 8 h / 0 °C
3: H2 / Ru(OCOCF3)2<(S)-tolbinap> / methanol / 100 h / 30 °C / 76000.1 Torr
View Scheme
参考文献
Kitamura, M.; Hsiao, Yi; Noyori, R.; Takaya, H.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4829 - 4832
