2,9-二氯-1,10-菲罗啉合成路线 （共 23 条）
反应条件
1: With phosphorus pentachloride; trichlorophosphate Inert atmospherecooling with iceReflux; 2: With ammonia in water Alkaline conditions;
参考文献
B.R.A.H.M.S GmbH; HOSHINO, Mikio; YANO, Toshisada; YAMANAKA, Yasukazu
Patent: WO2012/124310 A1, 2012 ;
Location in patent: Page/Page column 35 ;
反应条件
phosphorus pentachloride; trichlorophosphate T=110°C; 8 h;
参考文献
Annibale, Vincent T.; Batcup, Rhys; Bai, Tao; Hughes, Sarah J.; Song, Datong
Organometallics, 2013 , vol. 32, # 21 p. 6511 - 6521
反应条件
Yield given. Multistep reaction;
参考文献
Eggers, Friederike; Luening, Ulrich
European Journal of Organic Chemistry, 2009 , # 14 p. 2328 - 2341
反应条件
1: benzene / 3 h / 60 °C 2: K3<Fe(CN)6>, conc. NaOH / 3 h / 5 °C 3: PCl5, POCl3 / 8 h / Heating 4: 3 h / Heating 5: K3<Fe(CN)6>, conc. NaOH / 3 h / 5 °C 6: PCl5, POCl3 / 8 h / Heating View Scheme
参考文献
Eisai RandD Management Co., Ltd.; SANKO JUNYAKU CO., LTD.; HOSHINO, Mikio; YANO, Toshisada
Patent: WO2011/30566 A1, 2011 ;
反应条件
1: PCl5, POCl3 / 8 h / Heating 2: 3 h / Heating 3: K3<Fe(CN)6>, conc. NaOH / 3 h / 5 °C 4: PCl5, POCl3 / 8 h / Heating View Scheme
参考文献
B.R.A.H.M.S GmbH; HOSHINO, Mikio; YANO, Toshisada; YAMANAKA, Yasukazu
Patent: WO2012/124310 A1, 2012 ;
反应条件
1.1: potassium hexacyanoferrate(III); sodium hydroxide / water / 10 - 20 °C 2.1: phosphorus pentachloride; trichlorophosphate / Inert atmosphere; Cooling in ice; Reflux 2.2: Alkaline conditions 3.1: 20 - 120 °C / Inert atmosphere 4.1: potassium hexacyanoferrate(III); sodium hydroxide / water / 20 °C / Cooling with ice 5.1: phosphorus pentachloride; trichlorophosphate / Inert atmosphere; cooling with ice; Reflux 5.2: Alkaline conditions View Scheme
参考文献
B.R.A.H.M.S GmbH; HOSHINO, Mikio; YANO, Toshisada; YAMANAKA, Yasukazu
Patent: WO2012/124310 A1, 2012 ;
反应条件
1.1: potassium hexacyanoferrate(III); sodium hydroxide / water / 20 °C / Cooling with ice 2.1: phosphorus pentachloride; trichlorophosphate / Inert atmosphere; cooling with ice; Reflux 2.2: Alkaline conditions View Scheme
参考文献
B.R.A.H.M.S GmbH; HOSHINO, Mikio; YANO, Toshisada; YAMANAKA, Yasukazu
Patent: WO2012/124310 A1, 2012 ;
反应条件
1: potassium hexacyanoferrate(III); sodium hydroxide / water / 0 °C 2: trichlorophosphate; phosphorus pentachloride / 110 °C View Scheme
参考文献
Kremer, Christopher; Schnakenburg, Gregor; Lutzen, Arne
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 814 - 824
反应条件
phosphorus pentachloride; trichlorophosphate T=110°C; 8 h; Inert atmosphere;
参考文献
Staats, Holger; Eggers, Friederike; Hass, Oliver; Fahrenkrug, Frank; Matthey, Jens; Luening, Ulrich; Luetzen, Arne
European Journal of Organic Chemistry, 2009 , # 28 p. 4777 - 4792
反应条件
1: K3<Fe(CN)6>, conc. NaOH / 3 h / 5 °C 2: PCl5, POCl3 / 8 h / Heating View Scheme
参考文献
Costamagna, J.; Canales, J.; Vargas, J.; Alvarado, A.; Ferraudi, G.
Journal of the Indian Chemical Society, 1993 , vol. 70, # 11-12 p. 877 - 884
