3-氯-N-羟基苯甲醛肟氯化物合成路线 （共 10 条）
反应条件
hydrogenchloride; OXONE; water in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
Location in patent: Page/Page column 31; 32 ;
反应条件
N-chloro-succinimide T=20°C; 1 h;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 161-162 ;
WO 2004/014881 A2
反应条件
1: aq. NH2OH*HCl; AcONa / ethanol / 12 h 2: N-chlorosuccinimide; pyridine / CHCl3; tetrahydrofuran / 2 h View Scheme
参考文献
Liu, Kou-Chang; Shelton, Becky R.; Howe, Robert K.
Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3916 - 3918
反应条件
triethylamine in diethyl ether T=-10 - 0°C; 0.166667 h;
参考文献
Vitale, Paola; Tacconelli, Stefania; Perrone, Maria Grazia; Malerba, Paola; Simone, Laura; Scilimati, Antonio; Lavecchia, Antonio; Dovizio, Melania; Marcantoni, Emanuela; Bruno, Annalisa; Patrignani, Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4277 - 4299
反应条件
triethylamine; thiourea in tetrahydrofuran Ambient temperature;
参考文献
Kim, Jae Nyoung; Ryu, Eung K.
Tetrahedron Letters, 1993 , vol. 34, # 51 p. 8283 - 8284
反应条件
1: NaOMe / methanol / 20 °C
2: 100 percent / aq. NaOH / methanol
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
反应条件
(i) Na, MeOH, (ii) /BRN= 2575898/, (iii) aq. KOH; Multistep reaction;
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5838 - 5845
反应条件
1: ethyl acetoacetate With sodium in methanol
T=20°C; 0.25 h;
2: N-hydroxy-3-chloro-benzenecarboximidoyl chloride in methanol
T=20°C; 4.33333 h;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
Location in patent: Page/Page column 32 ;
反应条件
triethylamine in ethanol
T=20°C;
参考文献
Zamponi, Gerald W.; Stotz, Stephanie C.; Staples, Richard J.; Andro, Tina M.; Nelson, Jared K.; Hulubei, Victoria; Blumenfeld, Alex; Natale, Nicholas R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 87 - 96
反应条件
1.1: sodium / methanol / 4 h / 20 °C
2.1: sodium hydroxide / ethanol; water / 1 h / |Reflux
3.1: triethylamine / tetrahydrofuran / -10 - -5 °C
3.2: -10 - 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
